ChIPping away at gene regulation.

Chipping Away at the Perception/Production Interface

A Key to the Utilization of the Total Tree

to resaws. As the chipping headrig operator adjusts the cutterheads for a really ~lose shave, the rounded surface of the log is chipped away, leaving a log-length square timber. The whiskers are the chips. Instead of ntaking sawdust as conventional sawing techniques would, the chipping headrig makes chips, a valuable commodity to anyone who happens to own a paper mill. The chipping headrig kiss...

Smoothing a rock by chipping.

We investigate an idealized model for the size reduction and smoothing of a polygonal rock due to repeated chipping at corners. Each chip is sufficiently small so that only a single corner and a fraction of its two adjacent sides are cut from the object in a single chipping event. After many chips have been cut away, the resulting shape of the rock is generally anisotropic, with facet lengths a...

Microarrays: Chipping Away at the Mysteries of Science and Medicine

With only a few exceptions, every cell of the body contains a full set of chromosomes and identical genes. Only a fraction of these genes are turned on, however, and it is the subset that is "expressed" that confers unique properties to each cell type. "Gene expression" is the term used to describe the transcription of the information contained within the DNA, the repository of genetic informat...

Chipping away at the Embryonic Stem Cell Network

Critical transcription factors, notably OCT4, SOX2, and NANOG, are necessary to maintain self-renewal and pluripotency, two properties characteristic of embryonic stem (ES) cells. By analyzing the genome-wide localization of these factors at promoter regions in human ES cells, Boyer et al. (2005) demonstrate frequent promoter co-occupancy at numerous target genes. As they discuss in this issue ...